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Contenuto fornito da MasterMedFacts LLC and RR Baliga MD. Tutti i contenuti dei podcast, inclusi episodi, grafica e descrizioni dei podcast, vengono caricati e forniti direttamente da MasterMedFacts LLC and RR Baliga MD o dal partner della piattaforma podcast. Se ritieni che qualcuno stia utilizzando la tua opera protetta da copyright senza la tua autorizzazione, puoi seguire la procedura descritta qui https://it.player.fm/legal.
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Novel Therapeutics for Reduction of Lipoprotein (a)
Manage episode 465629302 series 2740117
Contenuto fornito da MasterMedFacts LLC and RR Baliga MD. Tutti i contenuti dei podcast, inclusi episodi, grafica e descrizioni dei podcast, vengono caricati e forniti direttamente da MasterMedFacts LLC and RR Baliga MD o dal partner della piattaforma podcast. Se ritieni che qualcuno stia utilizzando la tua opera protetta da copyright senza la tua autorizzazione, puoi seguire la procedura descritta qui https://it.player.fm/legal.
Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Traditional lipid-lowering therapies have minimal impact on Lp(a), necessitating novel treatments.
Zerlasiran, a small-interfering RNA (siRNA), significantly reduces Lp(a) (~85%) by inhibiting hepatic apolipoprotein(a) synthesis via subcutaneous injection.
Muvalaplin, an oral small-molecule inhibitor, prevents Lp(a) particle formation, reducing levels by up to 85.8%. Both drugs were well-tolerated in Phase 2 trials, with further studies needed to evaluate cardiovascular event reduction.
373 episodi
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Manage episode 465629302 series 2740117
Contenuto fornito da MasterMedFacts LLC and RR Baliga MD. Tutti i contenuti dei podcast, inclusi episodi, grafica e descrizioni dei podcast, vengono caricati e forniti direttamente da MasterMedFacts LLC and RR Baliga MD o dal partner della piattaforma podcast. Se ritieni che qualcuno stia utilizzando la tua opera protetta da copyright senza la tua autorizzazione, puoi seguire la procedura descritta qui https://it.player.fm/legal.
Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Traditional lipid-lowering therapies have minimal impact on Lp(a), necessitating novel treatments.
Zerlasiran, a small-interfering RNA (siRNA), significantly reduces Lp(a) (~85%) by inhibiting hepatic apolipoprotein(a) synthesis via subcutaneous injection.
Muvalaplin, an oral small-molecule inhibitor, prevents Lp(a) particle formation, reducing levels by up to 85.8%. Both drugs were well-tolerated in Phase 2 trials, with further studies needed to evaluate cardiovascular event reduction.
373 episodi
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Simile a Dr RR Baliga's "Got Knowledge Doc" Podkast
The BMJ brings you interviews with the people who are shaping medicine and science around the world.
…
continue reading
An award-winning cannabis podcast for women, by women. Hear joyful stories and useful advice about cannabis for health, well-being, and fun—especially for needs specific to women like stress, sleep, and sex. We cover everything from: What’s the best weed for sex? Can I use CBD for menstrual cramps? What are the effects of the Harlequin strain or Gelato strain? And, why do we prefer to call it “cannabis” instead of “marijuana”? We also hear from you: your first time buying legal weed, and how ...
…
continue reading
Learn the connection between what you eat and how you feel. Join us each week as licensed nutritionists and dietitians from Nutritional Weight & Wellness share practical, real-life solutions for healthier living through balanced nutrition. For over 25 years, we’ve helped thousands of clients and listeners discover how real food – animal protein, healthy fat, nutrient-dense carbohydrates – can increase energy, stabilize moods, jumpstart metabolism, eliminate cravings, restore digestion, balan ...
…
continue reading
The Clever Investor Property Podcast is your go-to guide for smart property investing in Australia. Whether you’re a first-time investor or expanding your portfolio, we break down the strategies, market trends, and expert insights to help you build wealth through real estate. Delivered in bite-sized chunks, episode are no more than 20 minutes. Hosted by Owun Taylor an experienced property investor and strategist, this podcast covers: ✔️ Property market trends & economic insights ✔️ Investmen ...
…
continue reading
Join me for a weekly talk-through of IELTS topics to help you learn about the issues, vocabulary, tips and strategies you need to prepare. Find all my tips on my website ieltsetc.com and join the Members Academy for all the downloads, step-by-step online courses, and support to get you a Band 7+ in the #ielts test.
…
continue reading
The Art of Charm is where self-motivated people, just like you, come to learn from the company’s coaches about to how to master human dynamics, relationships, and becoming your best self with the help of Johnny and AJ, the company’s founders. Johnny and AJ bring their 11 years of coaching experience from their famous Bootcamps, where they host clients in Los Angeles from all over the world and they share their stories, best practices and themselves on this weekly podcast. Not only does The A ...
…
continue reading
Do your eyes glaze over when looking at a long list of annual health insurance enrollment options – or maybe while you’re trying to calculate how much you owe the IRS? You might be wondering the same thing we are: Where’s the guidebook for all of this grown-up stuff? Whether opening a bank account, refinancing student loans, or purchasing car insurance (...um, can we just roll the dice without it?), we’re just as confused as you are. Enter: “Grown-Up Stuff: How to Adult” a podcast dedicated ...
…
continue reading
In Pursuit of Personal Evolution - Everything we say we want is a means to an end. In my experience, that end is either pleasure or fulfillment. While I am an admitted pleasure-seeker, my core devotion is in pursuing deep fulfillment, with a primary focus on psychological and spiritual pathways. After a lifetime spent pursuing personal development and researching behavioral psychology, I find our greatest fulfillment coming from continually understanding ourselves and what we care about, and ...
…
continue reading
Welcome to the weekly podcast of Elevation Church led by Pastor Steven Furtick. To learn more visit our website at http://elevationchurch.org or download the Elevation App. To support this ministry and help us continue to reach people all around the world click here: http://ele.vc/WeX3nP
…
continue reading
Lyngso Fitness Academy presents: The Missing Piece, an audio offering about the mission, mindset and mechanics of completely transforming your life.Ever wondered what is holding your back from your best life? Your best self? You know that something is missing.Welcome to the Missing Piece. Hosted by Paul Lyngso, this podcast provides you everything you need to finally achieve the next level of satisfaction in your life. By transforming your life from the inside out, Paul offers actionable ste ...
…
continue reading
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