Episode 2: The Hallmarks of Cancer

PROSPER Natural Cancer CARE with Carla Wrenn

In this episode of PROSPER Natural Cancer CARE, Carla delves into the concept of the "Hallmarks of Cancer," as elucidated by Hanahan and Weinberg in their series of seminal papers published between 2000 and 2022. She discusses the various hallmarks or drivers of cancer, including genetic instability, sustained proliferation, and evasion of growth suppressors.

Carla explains the significance of the tumour microenvironment, a complex ecosystem surrounding a tumour that influences its growth and invasion into healthy tissues. She explores how mutual interactions between cancer cells and components of the tumour microenvironment impact treatment resistance and prognosis.

The episode highlights factors considered in cancer care, such as immunogenicity, inflammatory diseases, metabolic state, environmental exposures, and lifestyle factors. Carla emphasizes the importance of understanding how herbal medicines, nutritional therapies, and dietary/lifestyle choices can impact the hallmarks of cancer and support patients safely and effectively. Listeners are encouraged to explore the references provided.

Next Episode Preview: Join Carla in the next episode as she shares her journey supporting patients with cancer and introduces some remarkable individuals she's met along the way.

References:

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70. doi: 10.1016/s0092-8674(00)81683-9. PMID: 21376230.
2. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PMID: 21376230
3. Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022 Jan;12(1):31-46. doi: 10.1158/2159-8290.CD-21-1059. PMID: 35022204.
4. Chen KL, Jung P, Kulkoyluoglu-Cotul E, Liguori C, Lumibao J, Mazewski C, Ranard K, Rowles JL 3rd, Wang Y, Xue L, Madak-Erdogan Z. Impact of Diet and Nutrition on Cancer Hallmarks. J Cancer Prev Curr Res. 2017;7(4):240. doi: 10.15406/jcpcr.2017.07.00240. Epub 2017 Feb 17. PMID: 30581989; PMCID: PMC6301051.
5. Sameri S, Mohammadi C, Mehrabani M, Najafi R. Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancer. BMC Complement Med Ther. 2021 May 31;21(1):160. doi: 10.1186/s12906-021-03330-1. PMID: 34059044; PMCID: PMC8168007.
6. Bose S, Panda AK, Mukherjee S, Sa G. Curcumin and tumor immune-editing: resurrecting the immune system. Cell Div. 2015 Oct 12;10:6. doi: 10.1186/s13008-015-0012-z. PMID: 26464579; PMCID: PMC4603973.
7. Chen X, Li H. Bruceine D and Narclasine inhibit the proliferation of breast cancer cells and the prediction of potential drug targets. PLoS One. 2024 Jan 12;19(1):e0297203. doi: 10.1371/journal.pone.0297203. PMID: 38215156; PMCID: PMC10786365.
8. Farahzadi R, Hejazi MS, Molavi O, Pishgahzadeh E, Montazersaheb S, Jafari S. Clinical Significance of Carniti

Find PROSPER Natural Cancer CARE on Instagram @prosper.cancer.care or visit www.prospercancercare.co.

For more information or to get in touch, connect with Carla on Instagram @carlawrenn or visit www.carlawrenn.com.

Disclaimer: This podcast is intended to be informational only and represents the opinion of the participants, but not necessarily their workplace. It is not intended to be used as medical advice and does not take the place of advice from a qualified health care practitioner in a clinical setting. Please check with your healthcare practitioner before embarking upon any of the treatments or lifestyle changes discussed.