Targeting the Fc Receptor Pathway to Treat Red Blood Cell Alloimmunization


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Program Chairman: Roberto Romero, MD, DMedSci Chief, Perinatology Research Branch Division of Maternal-Fetal Medicine and Obstetrics Division of Intramural Research NICHD/NIH/DHHS Editor-in-Chief for Obstetrics The American Journal of Obstetrics and Gynecology How well do you understand the biology of hemolytic disease of the fetus and newborn (HDFN)? What about its connection to the FcRn receptor pathway and IgG? Drs. Lee Shulman and Ken Moise go beyond the basics taught in medical school immunology and look more closely at FcRn’s role in protecting IgG. With an improved understanding of these mechanisms, we can expand therapeutic targets beyond the fetus and newborn and finally put the needles away.

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