Episode 279: A New Framework for Researching, Diagnosing, and Treating MS with Professor Tanja Kuhlmann

RealTalk MS

Every episode of RealTalk MS features updates and reports about emerging science. And, as you listen, some of you may wonder, 'When will these scientific achievements benefit me? When will these breakthroughs and advancements make their way from the laboratory workbench to the clinic?' That's exactly what the panel of MS experts who comprise the International Advisory Committee on Clinical Trials in MS are proposing in a new framework that leverages what scientists are continuing to learn and re-defines how we talk about MS, research MS, diagnose MS, and treat MS.

The new framework being recommended by the committee is broadly outlined in a paper that was published about 8 weeks ago. Joining me to discuss what this proposed framework is all about is the paper's lead author, Professor Tanja Kuhlmann.

We're also talking about the new high-efficacy disease-modifying therapy that received its FDA approval last week.

We're sharing the details behind the FDA's approval of a Phase 3 clinical trial for Masitinib, an investigational therapy for treating progressive MS.

We'll tell you about Abata Therapeutics' first T-cell treatment candidate for treating progressive MS.

And you'll hear about the results of a study that compared the outcome of treating people living with secondary progressive MS with autologous hematopoietic stem cell transplantation (aHSCT) versus treatment by disease-modifying therapies.

We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: Experts recommend a new framework for researching, diagnosing, and treating MS :22

FDA approves Ublituximab (Briumvi), an anti-cd20 disease-modifying therapy 1:12

FDA approves Phase 3 clinical trial for Masitinib as a treatment for progressive MS 4:35

Abata Therapeutics announces its first T-cell therapy candidate to treat progressive MS 7:20

Study shows aHSCT more effective than DMTs in treating secondary progressive MS 10:14

Professor Tanja Kuhlmann discusses a new framework for researching, diagnosing, and treating MS 13:51

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LINKS

If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

STUDY: Ublituximab versus Teriflunomide in Relapsing Multiple Sclerosis https://nejm.org/doi/full/10.1056/NEJMoa2201904

AB Science https://ab-science.com

RealTalk MS Episode 205: A Potentially Transformational Therapy for Progressive MS with Samantha Singer and Dr. Richard Ransohoff https://realtalkms.com/205

STUDY: Hematopoietic Stem Cell Transplantation in People with Active Secondary Progressive MS https://n.neurology.org/content/early/2022/12/21/WNL.0000000000206750

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RealTalk MS Episode 279 Guest: Professor Tanja Kuhlmann

Tags: MS, MultipleSclerosis, MSResearch, MSSociety, RealTalkMS

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