TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.
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The podcast for microbe lovers: reporting on exciting news about bacteria, archaea, and sometimes even eukaryotic microbes and viruses.
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Audio narrations of LessWrong posts. Includes all curated posts and all posts with 125+ karma. If you'd like more, subscribe to the “Lesswrong (30+ karma)” feed.
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This is a link post.Content warning: About an IRL death. Today's post isn’t so much an essay as a recommendation for two bodies of work on the same topic: Tom Mahood's blog posts and Adam “KarmaFrog1” Marsland's videos on the 2010 disappearance of Bill Ewasko, who went for a day hike in Joshua Tree National Park and dropped out of contact. 2010 – B…
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Crossposted from the AI Alignment Forum. May contain more technical jargon than usual.This is a link post.Is AI takeover like a nuclear meltdown? A coup? A plane crash? My day job is thinking about safety measures that aim to reduce catastrophic risks from AI (especially risks from egregious misalignment). The two main themes of this work are the d…
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[This article was originally published on Dan Elton's blog, More is Different.] Cerebrolysin is an unregulated medical product made from enzymatically digested pig brain tissue. Hundreds of scientific papers claim that it boosts BDNF, stimulates neurogenesis, and can help treat numerous neural diseases. It is widely used by doctors around the world…
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This work was produced at Apollo Research, based on initial research done at MATS. LayerNorm is annoying for mechanstic interpretability research (“[...] reason #78 for why interpretability researchers hate LayerNorm” – Anthropic, 2023). Here's a Hugging Face link to a GPT2-small model without any LayerNorm. The final model is only slightly worse t…
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This is slightly old news at this point, but: as part of MIRI's recent strategy pivot, they've eliminated the Agent Foundations research team. I've been out of a job for a little over a month now. Much of my research time in the first half of the year was eaten up by engaging with the decision process that resulted in this, and later, applying to g…
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This is a story about a flawed Manifold market, about how easy it is to buy significant objective-sounding publicity for your preferred politics, and about why I've downgraded my respect for all but the largest prediction markets. I've had a Manifold account for a while, but I didn't use it much until I saw and became irked by this market on the co…
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Cross-posted from Substack. 1. And the sky opened, and from the celestial firmament descended a cube of ivory the size of a skyscraper, lifted by ten thousand cherubim and seraphim. And the cube slowly landed among the children of men, crushing the frail metal beams of the Golden Gate Bridge under its supernatural weight. On its surface were inscri…
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Crossposted from the AI Alignment Forum. May contain more technical jargon than usual.What the heck is up with “corrigibility”? For most of my career, I had a sense that it was a grab-bag of properties that seemed nice in theory but hard to get in practice, perhaps due to being incompatible with agency. Then, last year, I spent some time revisiting…
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“Self-Other Overlap: A Neglected Approach to AI Alignment” by Marc Carauleanu, Mike Vaiana, Judd Rosenblatt, Diogo de Lucena
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Figure 1. Image generated by DALL-3 to represent the concept of self-other overlapMany thanks to Bogdan Ionut-Cirstea, Steve Byrnes, Gunnar Zarnacke, Jack Foxabbott and Seong Hah Cho for critical comments and feedback on earlier and ongoing versions of this work. Summary In this post, we introduce self-other overlap training: optimizing for similar…
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TL;DR: Your discernment in a subject often improves as you dedicate time and attention to that subject. The space of possible subjects is huge, so on average your discernment is terrible, relative to what it could be. This is a serious problem if you create a machine that does everyone's job for them. See also: Reality has a surprising amount of de…
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NB. I am on the Google Deepmind language model interpretability team. But the arguments/views in this post are my own, and shouldn't be read as a team position. “It would be very convenient if the individual neurons of artificial neural networks corresponded to cleanly interpretable features of the input. For example, in an “ideal” ImageNet classif…
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Sean Murphy joins TWiP to discuss his career and the work of his laboratory to assess the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda. Hosts: Vincent Racaniello, Dickson Despommier and Christina Naula Guest: Sean Murphy Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Link…
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“‘AI achieves silver-medal standard solving International Mathematical Olympiad problems’” by gjm
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This is a link post.Google DeepMind reports on a system for solving mathematical problems that allegedly is able to give complete solutions to four of the six problems on the 2024 IMO, putting it near the top of the silver-medal category. Well, actually, two systems for solving mathematical problems: AlphaProof, which is more general-purpose, and A…
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This is a link post.What is an agent? It's a slippery concept with no commonly accepted formal definition, but informally the concept seems to be useful. One angle on it is Dennett's Intentional Stance: we think of an entity as being an agent if we can more easily predict it by treating it as having some beliefs and desires which guide its actions.…
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(Crossposted from Twitter) I'm skeptical that Universal Basic Income can get rid of grinding poverty, since somehow humanity's 100-fold productivity increase (since the days of agriculture) didn't eliminate poverty. Some of my friends reply, "What do you mean, poverty is still around? 'Poor' people today, in Western countries, have a lot to legitim…
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TWiP solves the case of the AIDS patient who developed fever and watery diarrhea after drinking NYC tap water, and present a new case for your sleuthing. Hosts: Vincent Racaniello and Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Cryptosporidium (TWiP 18) Letter…
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Eliezer Yudkowsky periodically complains about people coming up with questionable plans with questionable assumptions to deal with AI, and then either: Saying "well, if this assumption doesn't hold, we're doomed, so we might as well assume it's true." Worse: coming up with cope-y reasons to assume that the assumption isn't even questionable at all.…
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This post was inspired by some talks at the recent LessOnline conference including one by LessWrong user “Gene Smith”. Let's say you want to have a “designer baby”. Genetically extraordinary in some way — super athletic, super beautiful, whatever. 6’5”, blue eyes, with a trust fund. Ethics aside[1], what would be necessary to actually do this? Fund…
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This is a link post.Editor's note: Somewhat after I posted this on my own blog, Max Chiswick cornered me at LessOnline / Manifest and gave me a whole new perspective on this topic. I now believe that there is a way to use poker to sharpen epistemics that works dramatically better than anything I had been considering. I hope to write it up—together …
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“Reliable Sources: The Story of David Gerard” by TracingWoodgrains
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This is a linkpost for https://www.tracingwoodgrains.com/p/reliable-sources-how-wikipedia-admin, posted in full here given its relevance to this community. Gerard has been one of the longest-standing malicious critics of the rationalist and EA communities and has done remarkable amounts of work to shape their public images behind the scenes. Note: …
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xlr8harder writes: In general I don’t think an uploaded mind is you, but rather a copy. But one thought experiment makes me question this. A Ship of Theseus concept where individual neurons are replaced one at a time with a nanotechnological functional equivalent. Are you still you? Presumably the question xlr8harder cares about here isn't semantic…
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TWiP 238: Eliminating sleeping sickness
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Michael Barrett joins TWiP to discuss progress in the elimination of human African trypanosomiasis caused by Trypanosoma brucei gambiense. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Michael Barrett Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Elimina…
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“80,000 hours should remove OpenAI from the Job Board (and similar orgs should do similarly)” by Raemon
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I haven't shared this post with other relevant parties – my experience has been that private discussion of this sort of thing is more paralyzing than helpful. I might change my mind in the resulting discussion, but, I prefer that discussion to be public. I think 80,000 hours should remove OpenAI from its job board, and similar EA job placement serv…
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This is a linkpost for https://www.bhauth.com/blog/biology/cancer%20vaccines.html cancer neoantigens For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mu…
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I Imagine an alternate version of the Effective Altruism movement, whose early influences came from socialist intellectual communities such as the Fabian Society, as opposed to the rationalist diaspora. Let's name this hypothetical movement the Effective Samaritans. Like the EA movement of today, they believe in doing as much good as possible, what…
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About a year ago I decided to try using one of those apps where you tie your goals to some kind of financial penalty. The specific one I tried is Forfeit, which I liked the look of because it's relatively simple, you set single tasks which you have to verify you have completed with a photo. I’m generally pretty sceptical of productivity systems, to…
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An NII machine in Nogales, AZ. (Image source)There's bound to be a lot of discussion of the Biden-Trump presidential debates last night, but I want to skip all the political prognostication and talk about the real issue: fentanyl-detecting machines. Joe Biden says: And I wanted to make sure we use the machinery that can detect fentanyl, these big m…
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