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A Naturally Occurring Bacterium Inhibits Malaria Parasites in the Mosquito
Manage episode 386124467 series 3531530
Contenuto fornito da Johns Hopkins Malaria Research Institute and Johns Hopkins Bloomberg School of Public Health. Tutti i contenuti dei podcast, inclusi episodi, grafica e descrizioni dei podcast, vengono caricati e forniti direttamente da Johns Hopkins Malaria Research Institute and Johns Hopkins Bloomberg School of Public Health o dal partner della piattaforma podcast. Se ritieni che qualcuno stia utilizzando la tua opera protetta da copyright senza la tua autorizzazione, puoi seguire la procedura descritta qui https://it.player.fm/legal.
A naturally occurring bacterium renders the mosquito a poor transmitter of the malaria parasite.
Transcript
Scientists often grow mosquitos in the laboratory and infect them with malaria parasites to test new drugs and explore vector control. Unexpectedly, in a lab run by GSK in Spain, mosquitoes gradually lost the ability to sustain parasite development. To unwind this mystery, GSK turned to Marcelo Jacobs-Lorena, a researcher at Johns Hopkins University and sent him a bacterium they suspected was the blocking agent. The Hopkins team determined that these bacteria produce a substance called harmane – a strong poison to the malaria parasite without affecting the mosquito. Harmane kills the parasite in the mosquito either by ingestion or by contact--when the mosquito lands on a surface with harmane on it. Further experiments determined that this Delftia bacterium colonizes the mosquitoes for life where it suppresses survival of the parasite. Experiments conducted by researchers in Burkina Faso showed that this bacterium can efficiently colonize mosquitoes under conditions that simulate those of the field and that it inhibits locally circulating parasites. This bacterium promises to be developed into a new tool to combat malaria.
Source
Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes
About The Podcast
The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
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