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EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick
Manage episode 393540661 series 2631947
Contenuto fornito da Sano Genetics. Tutti i contenuti dei podcast, inclusi episodi, grafica e descrizioni dei podcast, vengono caricati e forniti direttamente da Sano Genetics o dal partner della piattaforma podcast. Se ritieni che qualcuno stia utilizzando la tua opera protetta da copyright senza la tua autorizzazione, puoi seguire la procedura descritta qui https://it.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
179 episodi
Manage episode 393540661 series 2631947
Contenuto fornito da Sano Genetics. Tutti i contenuti dei podcast, inclusi episodi, grafica e descrizioni dei podcast, vengono caricati e forniti direttamente da Sano Genetics o dal partner della piattaforma podcast. Se ritieni che qualcuno stia utilizzando la tua opera protetta da copyright senza la tua autorizzazione, puoi seguire la procedura descritta qui https://it.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
179 episodi
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