SMT Comparison Of Short-Term Effects & GLP-1 And Obesity-Associated Cancers

The Chiropractic Forward Podcast: Evidence-based Chiropractic Advocacy

CF 345: SMT Comparison Of Short-Term Effects & GLP-1 And Obesity-Associated Cancers Today we’re going to talk about SMT Comparison Of Short Term Effects & GLP-1 And Obesity-Associated Cancers But first, here’s that sweet sweet bumper music

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OK, we are back and you have found the Chiropractic Forward Podcast where we are giving evidence-based chiropractic a little personality and making it profitable. We’re not the stuffy, elitist, pretentious kind of research. We’re research talk over a couple of beers. So grab you a bushel. I’m Dr. Jeff Williams and I’m your host for the Chiropractic Forward podcast. I’m so glad you’re spending your time with us learning together. Chiropractors – I’m hiring at my personal clinic. I need talent, ambition, smarts, personality, and easy to get along with associates. If this is you and Amarillo, TX is your speed, send me an email at [e-mail] If you haven’t yet I have a few things you should do.

• Go to Amazon and check our my book called The Remarkable Truth About Chiropractic: A Unique Journey Into The Research. It’s excellent resource for you and is categorized into sections so the information is easy to find and written in a way that is easy to understand for everyone. It’s on Amazon. That’s the Remarkable Truth About Chiropractic by Jeff Williams.
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You have found yourself smack dab in the middle of Episode #345 Now if you missed last week’s episode, we talked about Obesity In Adolescents & Combined Cognitive Behavioral Therapy and Physical Therapy Make sure you don’t miss that info. Keep up with the class.

On the personal end of things….. Let’s talk about a two-week break shall we? Yes, I took two weeks off from the podcast becasue I basically had to. My wife and daughter and I went to NYC. We left on a Thursday and returned on a Tuesday. My business has kind of exploded lately and there simply was not enough time in either of those two weeks to get the podcast recorded. One day I had 60. Just me as a solo doc. That’s tough. No time for talkie talkie. Now that I’m recovering and we’re sort of back to a normal week, I’m back at it.

First thing’s first, NYC was amazing. I went fully expecting to hate everything about it and I have to say….it was just sort of awesome. I didn’t hate it at all. The people were great for the most part. There are some odd folks in NYC but not as many as those of us outside the city would think. I relate to WAY more than I ever expected. They’re just hard working, get it done folks like we are in Texas. Just different accents.

I found New Yorkers friendlier than I expected. Except for a handful of them The NBC tour was a highlight as well as the mafia tour. I’m not Italian but I loved Little Italy. We actually spent quite a bit of time there. I’m going to make some of you disappointed here but we never used the subway. Not once. We used Lyft everywhere. First of all, I got 10x points on Lyft with my Chase Sapphire Reserve card so…..there’s that. Also, while you might say I missed out on an ‘experience’, from what I heard, it’s not all that great of one. Lol. On the other hand, I’d argue that we got to see a TON of the city by driving through it rather than riding under it. And I love the metro in DC so I’ve done the subway thing lots of times before. Just not in NYC. The high line was cool.

DUMBO wasn’t all that cool. I loved Central Park. The Met was by far the best museum out there. The Museum of Natural History was just blah. The Smithsonian in DC was much better. But the Met….that was awesome All the food….so good. The only way the New Yorkers are skinny is from all that walking. There’s not other excuse. The food is ridiculous. We saw Moulin Rouge on Broadway….very cool. Top of the Rock was great. I love Art Deco and Rockefeller Plaza is the epitome of Art Deco, man. It was gorgeous.

All in all it was great. I didn’t care much about it all but went with an open mind and absolutely loved the weekend. There’s something about it. It’s ‘electric’ somehow. I wouldn’t want to live in it all day every day but we loved the visit and we will most definitely be back sooner rather than later. Now that you have my impressions of NYC, as if you cared….losing that business while I was gone….ugh. We were just hitting our stride. But that’s OK, we have to have a life. We have to live and work can’t be all we do or we’ll go crazy.

Especially in our 50’s after almsot 27 years in the game. We have to have breaks and new experiences. Regardless of the hit to business. Now I’m not advocating going on a trip for a month or even 2 weeks. But 5-6-7 day visits somewhere…..yep….that’s OK and you should do it no less than once per quarter.

Just a tip from your ol uncle Jeffro….

Item #1 Our first one is called, “Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes” by Wang et al and published in JAMA Network Open on July 5, 2024 and that’s another hot tamale, hot tamale. Remember, the citations can be found at chiropracticforward.com under this episode. Wang L, Xu R, Kaelber DC, Berger NA. Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes. JAMA Netw Open. 2024;7(7):e2421305. doi:10.1001/jamanetworkopen.2024.21305

Why They Did It Is there clinical evidence supporting the potential benefits of glucagon-like peptide receptor agonists (GLP-1RAs) for the prevention of 13 obesity-associated cancers

How They Did It This retrospective cohort study was based on a nationwide multicenter database of electronic health records (EHRs) of 113 million US patients. The study population included 1 651 452 patients with T2D who had no prior diagnosis of obesity-associated cancers and were prescribed GLP-1RAs, insulins, or metformin during March 2005 to November 2018. Data analysis was conducted on April 26, 2024. Prescription of GLP-1RAs, insulins, or metformin.

Main Outcomes and Measures Incident (first-time) diagnosis of each of the 13 obesity-associated cancers occurring during a 15-year follow-up after the exposure was examined

What They Found

• GLP-1RAs compared with insulin were associated with a significant risk reduction in 10 of 13 obesity-associated cancers, including in gallbladder cancer, meningioma, pancreatic cancer, hepatocellular carcinoma, ovarian cancer, colorectal cancer, multiple myeloma, esophageal cancer, endometrial cancer, and kidney cancer.
• Although not statistically significant, the HR for stomach cancer was less than 1 among patients who took GLP-1RAs compared with those who took insulin.
• GLP-1RAs were not associated with a reduced risk of postmenopausal breast cancer or thyroid cancer.
• Of those cancers that showed a decreased risk among patients taking GLP-1RAs compared with those taking insulin, HRs for patients taking GLP-1RAs vs those taking metformin for colorectal and gallbladder cancer were less than 1, but the risk reduction was not statistically significant.
• Compared with metformin, GLP-1RAs were not associated with a decreased risk of any cancers, but were associated with an increased risk of kidney cancer

Wrap It Up In this study, GLP-1RAs were associated with lower risks of specific types of obesity-associated cancers compared with insulins or metformin in patients with T2D. These findings provide preliminary evidence of the potential benefit of GLP-1RAs for cancer prevention in high-risk populations and support further preclinical and clinical studies for the prevention of certain obesity-associated cancers.

Item #2 The last one this week is called, “Comparison of Short-Term Effects of Different Spinal Manipulations in Patients with Chronic Non-Specific Neck Pain: A Randomized Controlled Trial” by Garcia-Gonzalez et al and published in Healthcare in June of 2024, OMG it’s HOT people! García-González, J.; Romero-del Rey, R.; Martínez-Martín, V.; Requena-Mullor, M.; Alarcón-Rodríguez, R. Comparison of Short-Term Effects of Different Spinal Manipulations in Patients with Chronic Non-Specific Neck Pain: A Randomized Controlled Trial. Healthcare 2024, 12, 1348. https://doi.org/10.3390/healthcare12131348

Why They Did It Spinal manipulations for chronic non-specific neck pain (CNNP) include cervical, cervicothoracic junction, and thoracic spine (CCT) manipulations as well as upper cervical spine (UCS) manipulations. This study aimed to compare the short-term effects of upper cervical spine manipulation versus a combination of cervicothoracic junction, and thoracic spine spine manipulations on pain intensity, disability, and cervical range of motion (CROM) in chronic non-specific neck pain patients.

How They Did It In a private physiotherapy clinic, 186 participants with chronic non-specific neck pain were randomly assigned to either the upper cervical spine or cervicothoracic junction, and thoracic spine manipulation groups. Neck pain, disability, and cervical range of motion were measured before and one week after the intervention.

What They Found No significant differences were found between the groups regarding pain intensity and cervical range of motion. However, there was a statistically significant difference in neck disability, with the cervicothoracic junction, and thoracic spine group showing a slightly greater decrease

Wrap It Up The findings suggest that a combination of manipulations in the cervicothoracic junction, and thoracic spine spine results in a slightly more pronounced decrease in self-perceived disability compared to upper cervical spine manipulation in patients with chronic non-specific neck pain after one week. However, no statistically significant differences were observed between the groups in terms of pain intensity or cervical range of motion.

Alright, that’s it. Keep on keepin’ on. Keep changing our profession from your corner of the world. The world needs evidence-based, patient-centered practitioners driving the bus. The profession needs us in the ACA and involved in leadership of state associations.

So quit griping about the profession if you’re doing nothing to make it better. Get active, get involved, and make it happen. Let’s get to the message. Same as it is every week. Store Remember the evidence-informed brochures and posters at chiropracticforward.com.

Purchase Dr. Williams’s book, a perfect educational tool and chiropractic research reference for the daily practitioner, from the Amazon store TODAY!

The Message I want you to know with absolute certainty that when Chiropractic is at its best, you can’t beat the risk vs reward ratio because spinal pain is primarily a movement-related pain and typically responds better to movement-related treatment rather than chemical treatments like pills and shots. When compared to the traditional medical model, research and clinical experience show us patients can get good to excellent results for headaches, neck pain, back pain, and joint pain to name just a few. It’s safe and cost-effective can decrease surgeries & disability and we do it through conservative, non-surgical means with minimal hassle to the patient. And, if the patient treats preventatively after initial recovery, we can usually keep it that way while raising the overall level of health!

Key Point: At the end of the day, patients should have the guarantee of having the best treatment that offers the least harm. When it comes to non-complicated musculoskeletal complaints…. That’s Chiropractic!

Contact Send us an email at dr dot williams at chiropracticforward.com and let us know what you think of our show and tell us your suggestions for future episodes. Feedback and constructive criticism is a blessing and so are subscribes and excellent reviews on podcast platforms. We know how this works by now. If you value something, you have to share it, interact with it, review it, talk about it from time to time, and actively hit a few buttons to support it here and there when asked. It really does make a big difference.

Connect We can’t wait to connect with you again next week. From the Chiropractic Forward Podcast flight deck, this is Dr. Jeff Williams saying upward, onward, and forward.

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About the Author & Host Dr. Jeff Williams – Fellow of the International Academy of Neuromusculoskeletal Medicine (FIANM) and Board Certified Diplomate of the American Board of Forensic Professionals (DABFP) – Chiropractor in Amarillo, TX, Chiropractic Advocate, Author, Entrepreneur, Educator, Businessman, Marketer, and Healthcare Blogger & Vlogger

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