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Pamela Maher: Discovering Phytochemicals That May Protect the Brain Against Aging and Disease
Manage episode 419436176 series 3558288
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Many of the drugs that are used recreationally or prescribed by physicians were originally isolated from plants. Increasing evidence suggest that in many instances the function of such phytochemicals is to communicate with insects and other organisms in ways that enhance the fitness of the plants. Pamela Maher at the Salk Institute has been working to identify phytochemicals that can protect neurons from being damaged in experimental models of neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s disease.. Here she talks about several phytochemicals that are particularly promising including fisetin, sterubin, cannabinol, and a synthetic derivative of fisetin called CMS121.
LINKS:
Fisetin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990461/pdf/bpl-6-bpl200104.pdf
Sterubin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309122/pdf/main.pdf
CMS121: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394765/pdf/main.pdf
Cannabinol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002867/pdf/main.pdf
Perspective article on neuroprotective phytochemicals: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841445/pdf/nihms946635.pdf
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