044 - COVID, Autoimmunity, and why SARS-CoV-2 is dubbed "The Autoimmune Virus"

The Autoimmune Doc Podcast w/ Dr. Taylor Krick

Long Haulers UPDATED (video)

Long Haulers Mechanisms (video)
SARS-CoV-2 and the gut-brain-lung axis (video review of a research paper)
From the onset of the pandemic through the last (almost) 3 years, we have continued to find out new things about how people respond after coronavirus infection. Not surprisingly, there is more and more research coming out indicating that an increased autoimmune response may be responsible for many of the lingering symptoms.
Early on in the pandemic, SARS-CoV-2 was nicknamed "The Autoimmune Virus" because it appeared to be triggering more of an autoimmune response than other viral infections. As science has continued to evolve our understanding, it turns out that COVID infection is absolutely associated with increased autoimmunity - both exacerbation of existing autoimmunity as well as new autoimmunity.
Autoimmunity is the process in which the body "loses self tolerance" for tissues of the body and begins to initiate an immune "attack" against self-tissue (thyroid, joints, brain, gut, etc) as if they were a foreign invader - which leads to chronic inflammation, tissue damage, and a gradual loss of function, and can eventually become a diagnosed autoimmune "disease" like Type 1 Diabetes or Rheumatoid Arthritis.
One of the ways that viruses can trigger autoimmunity is by means of "molecular mimicry", or what can be described as a case of "mistaken identity". In this podcast I describe it like this - I have a blue F150 pickup truck, extended cab, long bed. There are many blue F150s on the road, so what if the police were looking for a blue F150 and they accidentally pull ME over instead of the bad guy they are looking for? That's a case of mistaken identity. Well COVID antibodies can also misdirect their immune attack, and they can accidentally attack many tissues, and in this episode I go through dozens of different autoantibodies that have now been associated with COVID - - thyroid autoantibodies, neurological autoantibodies, mitochondrial autoantibodies, and more.
We now know that COVID infection can lead to a myriad of symptoms, and they can all be described as the "long-haul", but the mechanisms can be all quite different, so they are NOT all the same thing, and it's not fair to group everyone together as "long-haulers". You could have POTS, dysautonomia, clotting/coagulation, neurological (depression, brain fog, and TONS of anxiety...), digestive changes, fatigue, or you could develop post-COVID diabetes or arthritis.....as science continues to learn more are we going to find that it's ALL autoimmune in nature?? Only time will tell, but I believe that treating any condition as if it were an autoimmune case is never a bad approach - decrease inflammation, balance the immune system, and look for (and remove) any root cause triggers!