🧬Barry Ticho - Part 2 | Zebrafish Hearts & Pediatric Cardiology | Balancing Lab Work & Clinical Practice | Navigating Academic Medicine's Challenges | The Draw of Biopharma & Translational Medicine

The Biotech Startups Podcast

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Part 2 of 4: Jon Chee hosts Barry Ticho, Founder of Verve Therapeutics and Chief Medical Officer at Stoke Therapeutics, a biotech company addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines.

With an MD-PhD from the University of Chicago and extensive experience across academia and industry, Barry brings over two decades of expertise in clinical development. His journey includes roles as Head of Development at Moderna, Head of External R&D Innovation at Pfizer, and VP of Clinical Development at Biogen, where he's been instrumental in advancing numerous therapeutic programs across multiple disease areas.

Barry's unique perspective spanning academic medicine and biotechnology innovation makes his insights invaluable for aspiring leaders in the field.

Join us this week to hear about:

• Pioneering research using transparent zebrafish embryos to study cardiac development
• Helping establish the myCHOICE program at University of Chicago
• Managing concurrent roles at Harvard Medical School and Mass General
• Gaining invaluable crisis management experience as a pediatric cardiologist leading emergency resuscitations
• Making the strategic career transition to biopharma to combine basic science with clinical work

Please enjoy Jon’s conversation with Barry Ticho.

Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994

Find Our Guest, Barry Ticho, at these links:

https://www.linkedin.com/in/barryticho/

https://www.stoketherapeutics.com/

https://www.vervetherapeutics.com/

Find Our Host, Jon Chee, at these links:

https://www.linkedin.com/in/jonchee

https://www.excedr.com

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Podcast Website: https://www.thebiotechstartupspodcast.com/

Enriched Notes:

Topics Mentioned:

Stoke Therapeutics https://www.stoketherapeutics.com/

Verve Therapeutics https://www.vervetherapeutics.com/

University of Chicago https://www.uchicago.edu/en

Harvard Medical School https://hms.harvard.edu/

Boston Children's Hospital https://www.childrenshospital.org/

Massachusetts General Hospital https://www.massgeneral.org/
Northwestern University https://www.northwestern.edu/

How to Spin Out of Academia: https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup

Breaking into BD as a PhD Student https://www.excedr.com/blog/how-to-break-into-biotech-bd-as-a-phd-student

Biotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support

Medical Imaging: Modalities & Types of Equipment https://www.excedr.com/blog/medical-imaging-and-radiology-overview

People Mentioned:

Mark Fishman https://www.linkedin.com/in/mark-fishman-1b1368182/

Timestamps:

00:00 Intro

02:16 Transitioning from grad school to Harvard and Boston Children's Hospital

04:19 The importance of rotations and exploring different career paths

06:48 Fascination with cardiac development: From four cells to a complex organ

08:24 Advice on continuous learning and career exploration

10:49 The shift in academia: From textbooks to startups

12:09 Zebrafish research: Transparent insights into cardiac development

14:44 The rewards and challenges of practicing pediatric cardiology

16:57 Learning from brilliant colleagues: "Steel sharpens steel"

18:18 Avoiding comparison: "Comparison is the thief of joy"

20:59 Gaining perspective on emergencies: From cardiac arrests to business crises

23:46 The catalyst for transitioning to industry: Combining science and clinical interests

26:27 The changing landscape of medicine and the appeal of biopharma

27:18 Outro

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