Amygdala vs. Dopamine: How Your Brain Handles Stress, Motivation, and Emotions

The Longevity Podcast: Optimizing HealthSpan & MindSpan

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We map the biology of fear from the autonomic seesaw to the HPA axis, then show how the amygdala links threat to motivation and how the prefrontal cortex writes the story that guides action. We share a two-step framework to extinguish old circuits and build stronger, positive ones with therapy, breathing, and smart supplement timing.
• clear definitions of fear, stress, anxiety and trauma
• autonomic nervous system and HPA axis explained
• cortisol’s role in long-term memory and wiring
• amygdala outputs to threat and reward systems
• conditioning, one-trial learning and generalisation
• extinction through safe re-exposure and narrative
• ketamine and MDMA assisted therapy mechanisms
• cyclic hyperventilation protocol and cautions
• sleep and nutrition as foundations for resilience
• saffron and inositol evidence and timing logic
• two-step blueprint to diminish and replace fear
This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.

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Capitoli

1. Defining Fear, Stress, Anxiety (00:00:00)

2. From Stress To Trauma (00:02:10)

3. Autonomic Seesaw And HPA Axis (00:02:55)

4. Cortisol, Memory, And The Amygdala (00:05:10)

5. Conditioning And One‑Trial Learning (00:07:00)

6. Extinction And Narrative Rebuilding (00:08:20)

7. Ketamine And MDMA Assisted Therapy (00:09:40)

8. Breathing Protocol And Safety (00:11:15)

9. Sleep, Nutrition, Supplements, Timing (00:12:05)

10. The Two‑Step Blueprint For Courage (00:12:40)