Dr. Dominic D’Agostino, PhD: Mastering Metabolism - The Intersection of Ketosis, Brain Health, and Elite Performance

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In this enlightening episode, I had the distinct honor of speaking with Dominic D’Agostino, Ph.D., an esteemed Associate Professor at the University of South Florida. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC), dedicating his vast expertise towards optimizing the health and resilience of both warfighters and astronauts. His remarkable background, which spans from neuropharmacology to physiology and from neuroscience to medical biochemistry, offers a unique perspective that makes him a thought leader in his fields.
Our in-depth discussion delved into the intricate details of metabolic health, with particular emphasis on the ketogenic diet and its impact on various conditions including epilepsy, cancer, and even Alzheimer's. Dr. D’Agostino shared invaluable insights into how the body's metabolism is intimately connected to overall health and well-being, including how ketone supplementation can play a pivotal role in brain health. The conversation didn’t stop there. We further ventured into the intriguing realm of CNS oxygen toxicity, discussing its profound implications on the brain, and the potential therapeutic avenues that might mitigate its effects.
I am confident that our listeners, whether familiar with these topics or just diving into the world of metabolic health, will find immense value in Dr. D’Agostino's insights. So, grab your headphones, find a cozy spot, and tune into this episode.
Dr. Dominic P. D'Agostino, affiliated with Audacious Nutrition, co-founded KETOSTART® to address the market's long-standing need for a trusted exogenous ketone supplement, delivering all the benefits of beta-hydroxybutyrate without the pitfalls of rushed and poorly researched product development. Their singular goal was to do it right, making KETOSTART stand out among the myriad of exogenous ketone supplements available.
Key Points From This Episode:

• Understanding ketosis' impact on the central nervous system [00:05:30]
• Exploring CNS oxygen toxicity [00:11:20]
• Diving into dietary protocols [00:15:45]
• Importance of self-monitoring and physiological baselines [00:20:40]
• Dominic's emphasis on journaling for health and training [00:24:50]
• Ketone esters require caution [00:34:40]
• Ketones have neuroprotective effects [00:38:48]
• Exogenous ketones can cause harm [00:45:20]
• Ketones may enhance mental performance [00:55:04]
• Discussing the metabolic health summit [01:23:42]

Links Mentioned in Today’s Episode:
Click HERE to save on BiOptimizers Magnesium
Audacious Nutrition
Peter Attia
Dr Richard Veech

Keto Nutrition

The Metabolic Link

Metabolic Health Summit

Dr Dominic on Twitter

Dr Dominic on Instagram

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Capitoli

1. Teaser (00:00:00)

2. Magnesium Supplement (00:00:16)

3. Introduction (00:03:42)

4. Impact of diets on bone mineral density (00:07:17)

5. Cellular function and total body wellness (00:13:22)

6. Exogenous ketones and performance (00:17:33)

7. Experimenting with Ketones (00:23:31)

8. Ketone esters and their effects (00:34:26)

9. Ketones and epilepsy mechanism (00:39:31)

10. Lifestyle change vs. exogenous supplementation (00:43:15)

11. Alternative energy sources (00:49:42)

12. Ketone supplementation and focus (00:58:06)

13. Ketones before bed (01:02:32)

14. Anxiolytic effect of ketosis (01:09:03)

15. Amenorrhea and ketogenic diets (01:16:48)

16. Baseline and functional biomarkers (01:21:05)

17. Metabolic health summit (01:24:40)

18. Outro (01:25:28)